IMHO pop-up blockers don't do any good. They only mask the real problem which will cause other difficulties down the road.
It sounds to me like you've got some adware/spyware on your system.
1st delete all your cache and cookies.
2nd get rid of the adware. The easiest way is to install an adware removal app like spybot or ad-aware.
I personally use ad-aware. You can get it here:
http://www.lavasoft.deRun that and delete what it finds. Run it on a regular basis, like when you would normally run a system scan with your antivirus app.
Avoid installing apps known to contain adware/spyware like kazaa, weatherbug, plugins for IE like search bars, etc.
A personal firewall can really help too.
I use IE on a regular basis and never get pop-ups.
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