I'm not quite sure what you were talking about, i wasn't sure if you were talking about Pixar or Pixels seeing how you were referring to Game design.
The thing is I'm currently studying multimedia design and i usually use adobe photoshop, Flash , Director if you are just starting off and aren't familiar with complicated programs , or if you are totally professional then definately use Maya or Lightwave 3d programs to design your games .
For 2d .. im definately sure Flash is by far the best program on this earth lol. Well I've currently been doing story board designs and short animation .. but its great. You can use it to draw your images and then at the same time animate it so i guess its all in one. Oh and if you stuff up your drawing , you can just fix it up by clicking on the lines and moving it around its like reshaping your images.
Anyways try it out and i wish you luck! lets see how your game turns out
