Hey, I found this article on Cnet where they rate and compare antispyware removal programs. The best thing is that you can download them for free from Cnet Download.com. I wont go on and give you the reviews, you have to go check them out, here is the link:

Cnet antispyware review

Hope this helps, and if it does some reputation would be Great.
Good Luck.!

There is a free program named Bazooka Adware and Spyware Scanner http://www.kephyr.com/spywarescanner/index.html it does not remove the spyware but it scans them on your computer and than it tells how to manually remove them. By my experience so far I would like to say that manual removal is more effective than any of the Adware/Spyware remover in the market be. I have tried a lot of these programs but in the end Bazooka did the best work. I am not saying that it is 100% effective but it will help you to remove most of the spyware/adware on your system. So I would suggest you or anybody who is suffering fro this problem.
And in the future after removal of these spyware/adwares use Firefox for better security. And keep one thing in the mind for adware/spyware Prevention is better than Cure.

Two tools of getting RID of Adware and Spyware of FREE!
Spybot S&D - http://www.safer-networking.org/en/index.html
Ad-Aware - http://www.lavasoft.com/

Test them out, they work good for me.

In addition to spybot and ad-aware use HiJackThis!

I find that combination of the three works the best. it takes a bit of care and patience with hijackThis but I think its the most effective. you can find a lot of HiJackThis tutorials on the web.

downlaod & initial instructions

& how to analyze the log

this one has some good info & links too

I wanted to take a moment to put my own two cents or so in. I have found that the Lavasoft Ad-Aware home edition which is free is a very good program for finding malicious spyware. Its a good idea to use more than one. Do do a virus scan and then do a adware scan. Do becareful of what programs you use too. Some of the advertised free adware/spyware removers are actually cleaverly disquised adware/spyware generators. Its also a good idea when you realize that you are having adware or spyware problems to look in your start menu for new programs. Sometmes you can find them in your add and remove program menu as well. Some of the none big name search engines will install their special toolbars on your computer which will also put adware on your computer. Some of the free gaming sites that are offshoots will put malicious software on your computer too. You have to watch those popups they will kick your buttt.

Do note that if the above advice from our fellow forum mates does not work then do a search with the names of the viruses and spyware. Sometimes you will find some good forums for that sort of thing. Take into consideration that some of the viruses and spyware have it in their programming to keep changing their names. So you may think you have caught the thing and it may come back. I spent a week trying to clean up my brother's computer once and well we tried everything under the sun before we had to give up and completely format the drive and start from scratch.

Its a royal pain in the butt to have to do a format and reinstall but if nothing else works that is your only option. Now if you have not done a format and reinstall I highly encourage you to look it up on the net and either print or write out the step by step instructions. Otherwise you are going to be completely lost. Also all computer users should backup their work. I know we get out of that habit but when things like this happen you are reminded why its so important.

Most of all don't feel to discouraged you are not alone. It happens to the best of us.

Another programm is hitman pro, but afterwards some things doesn't work anymore.
Like games with MSN messenger, to repair this you have to remove hitman pro from your computer.

You can download it from : http://www.hitmanpro.nl/
The site is written in dutch but since a few version the programs are setup in English.

It's easy to run and it cleanup a lot of spyware.
It runs several programs after eachother and it configures the programs also.

Works good.

If all else fails for you, buy Defender Pro 15-in-1 2007 from your local store.
I had the same problems you did plus more. Such as new adult links being put into my history, And homepage takeover.
I downloaded countless pregrams to fix it and none worked, so I bought Norton Internet Security 2007(which was the best program at the time) and it couldn't fix it. Then, I bought Spyware Doctor 2007, it found the files, but couldn't delete them. Finally, I found the savior: Defender Pro 15-in-1 2007. It fixed the problem plus it even has other programs that come with it that help your PC in other ways.

Norton Internet Security 2007 = 70$, Fixed problem: No
Spyware Doctor 2007 = 40$, Fixed problem: No
Defender Pro 15-in-1 2007 = 40$, Fixed problem: Heck yes!

I would say your best option is to reinstall windows. By the sound of it your computer has already become severely clogged.
It is often difficult to remove two viruses completely, let alone 150 bundled everywhere. Also as you're trying to remove them it will take a lot of time and you may never be able to restore the speed and performance you had before, with missed registry entries and everything they all changed.
Just remember to get off all the files that you need and make a list of all the programs you have currently (makes reinstalling everything back on easier).

Important if you are backing up files: by the time you come to put them back onto your clean system, make sure you scan them with some virusscanner or put them onto someones's computer who has and can then check if they are clean.
You don't want to be putting viruses back onto your system.!!

Good luck